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Initially focused on metabolism, research showed NNMT elevation with age/weight leads to fat accumulation, inefficiency, and NAD+ loss.[30][31] High NNMT correlates with insulin resistance and obesity in humans

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A study published in Endocrinology demonstrated that chronic treatment with the fragment in obese mice resulted in a reduction of adipose tissue mass without changes in lean body mass or food consumption

Its effects tend to diminish after 46 weeks of daily use, so strategic breaks are essential to reset the bodys responsiveness and restore its full effectiveness

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If 3.0 mg is not tolerated within 12 weeks, treatment should be reassessed, especially if less than 5% weight loss has occurred